Osseous Tumor Reporting and Data System—Multireader Validation Study
| Autor: | Anurag Gupta, Alexandra K. Callan, Parham Pezeshk, Paul T. Weatherall, Nathan Dettori, Uma Thakur, Avneesh Chhabra, Yin Xi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Validation study medicine.diagnostic_test Receiver operating characteristic business.industry Intraclass correlation Magnetic resonance imaging Guideline Malignancy medicine.disease Osseous Tumor Feature (computer vision) medicine Radiology Nuclear Medicine and imaging Radiology business |
| Zdroj: | Journal of Computer Assisted Tomography. 45:571-585 |
| ISSN: | 1532-3145 0363-8715 |
| DOI: | 10.1097/rct.0000000000001184 |
| Popis: | OBJECTIVE To develop and validate an Osseous Tumor Reporting and Data System (OT-RADS) with the hypothesis that the proposed guideline is reliable and assists in separating benign from malignant osseous tumors with a good area under the curve, and that could assist further patient management. METHODS In this multireader cross-sectional validation study, an agreement was reached for OT-RADS categories based on previously described magnetic resonance imaging features and consensus of expert musculoskeletal radiologists. World Health Organization classification was used, and a wide spectrum of benign and malignant osseous tumors was evaluated. Magnetic resonance imaging categories were as follows: OT-RADS 0-incomplete imaging; OT-RADS I-negative; OT-RADS II-definitely benign; OT-RADS III-probably benign; OT-RADS IV-suspicious for malignancy or indeterminate; OT-RADS V-highly suggestive of malignancy; and OT-RADS VI-known biopsy-proven malignancy or recurrent malignancy in the tumor bed. Four blinded readers categorized each tumor according to OT-RADS classification. Intraclass correlation (ICC) and Conger κ were used. Diagnostic performance measures including area under the receiver operating curve were reported. Osseous Tumor Reporting and Data System was dichotomized as benign (I-III) and malignant (IV and V) for calculating sensitivity and specificity. RESULTS Interreader agreement for OT-RADS (ICC = 0.78) and binary distinction of benign versus malignant (κ = 0.67) were good to excellent, while agreement for individual tumor feature characteristics were poor to fair (ICC = 0.25-0.36; κ = 0.16-0.39). The sensitivities, specificities, and area under the receiver operating curve of the readers ranged from 0.93-1.0, 0.71-0.86, and 0.92-0.97, respectively. CONCLUSIONS Osseous Tumor Reporting and Data System lexicon is reliable and helps stratify tumors into benign and malignant categories. It can be practically used by radiologists to guide patient management, improve multidisciplinary communications, and potentially impact outcomes. |
| Databáze: | OpenAIRE |
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