| Autor: |
Quanxin Wang, Yun Wang, Peng Xie, Hsien-Chi Kuo, Karla E Hirokawa, Maitham Naeemi, Shenqin Yao, Ben Ouellette, Matt Mallory, Phil Lesnar, Xiuli Kuang, Yaoyao Li, Min Ye, Chao Chen, Wei Xiong, Leila Ahmadinia, Laila El-Hifnawi, Ali Cetin, Julie A Harris, Hongkui Zeng, Christof Koch |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.1101/2022.02.23.481555 |
| Popis: |
SummaryThe claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. However, its regional anatomy and cell-type-specific connections in the mouse remain largely undetermined. Here, we accurately delineated the boundary of the mouse CLA and quantitatively investigated its inputs and outputs brain-wide using anterograde and retrograde viral tracing and fully reconstructed single claustral principal neurons. At a population level, the CLA reciprocally connects with all isocortical modules. It also receives inputs from at least 35 subcortical structures but sends projections back to only a few of them. We found that cell types projecting to the CLA are differentiated by cortical areas and layers. We classified single CLA principal neurons into at least 9 cell types that innervate the diverse sets of functionally linked cortical targets. Axons of interneurons within the CLA arborize along almost its entire anteroposterior extent. Together, this detailed wiring diagram of the cell-type-specific connections of the mouse CLA lays a foundation for studying its functions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
