A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q12

Autor: Derek J. Nancarrow, G Kalsi, Dermot Walsh, Hugh Gurling, J Brynjolfsson, Hannes Petursson, Jeremy M. Silverman, Kenneth S. Kendler, Robin M. Murray, T. d'Amato, Lynn R. Goldin, Hiroshi Kunugi, Robert B. Freedman, M. Jay, T. Sigmundson, W. Muri, Wolfgang Maier, William Byerley, J. Mallet, L. Yang, A. E. Pulver, C J MacLean, P. C. Sham, L. He, Raymond R. Crowe, R. E. Straub, Margot Albus, Dominique Campion, Michael John Owen, Richard P. Ebstein, Elliot S. Gershon, H. Donis-Keller, Hans W. Moises, Gerald Nestadt, D. H. R. Blackwood, Haig H. Kazazian, D. StClair, Claudine Laurent, Joachim Hallmayer, Claudia Wiese, D. B. Wildenauer, Stylianos E. Antonarakis, Bryan J. Mowry, Michael Gill, Homero Vallada, David E. Housman, H. Kristbjarnarson, R. Lofthouse, C. M. Read, Shinichiro Nanko, Mihael H. Polymeropoulos, P. McGuffin, Nicholas K. Hayward, H-G Hwu, S. Bodeau-Pean, Manfred Ackenheil, B. Lerer, David A. Collier, Douglas F. Levinson, Hilary Coon, Lynn E. DeLisi, J. H. Zhao, David Curtis, S. Maguire
Rok vydání: 1998
Předmět:
Zdroj: Schizophrenia Research. 32:115-121
ISSN: 0920-9964
Popis: Patients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene. We previously investigated the hypothesis that schizophrenia is negatively associated with DRB1*04, and found that only half the expected number of schizophrenic patients had this gene when compared with controls. We now report the results of DRB1*04 genotyping in pedigrees multiply affected with schizophrenia. Polymerase chain reaction amplification and sequence-specific oligonucleotide probes were used to determine the DRB1 genotypes of the 187 members of 23 pedigrees multiply affected with RDC schizophrenia. DQA1, DQB1 and DPB1 genotypes were similarly determined. We analysed data using the extended transmission/disequilibrium test and found a trend for the preferential non-transmission of DRB1*04 alleles from heterozygous parents to their schizophrenic offspring (16 of 23 alleles not transmitted, chi 2 = 3.5, p = 0.06). We found no evidence for a gene of major effect using GENEHUNTER for parametric and non-parametric linkage analysis. The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia.
Databáze: OpenAIRE
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