Process Research and Impurity Control Strategy for Obeticholic Acid, a Farnesoid X Receptor Agonist
| Autor: | Wei-Dong Feng, Song-Ming Zhuo, Fu-Li Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Agonist
Nonalcoholic steatohepatitis 010405 organic chemistry medicine.drug_class Chemistry Process research Organic Chemistry Obeticholic acid 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Impurity Yield (chemistry) medicine Farnesoid X receptor Physical and Theoretical Chemistry |
| Zdroj: | Organic Process Research & Development. 23:1979-1989 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.9b00252 |
| Popis: | The process to obtain ICH-grade quality obeticholic acid (OCA) was improved, and the overall yield was 25.9%. The critical process parameters were established to reduce or avoid process-related imp... |
| Databáze: | OpenAIRE |
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