| Autor: |
Bing Liu, Anna Appios, Ashley Moffett, Jake R. Thomas, Florent Ginhoux, Russell S. Hamilton, Roksana Dutkiewicz, Graham J. Burton, Joana Cerveira, Praveena Naidu, Andrew M. Sharkey, Naomi McGovern, Christopher H. T. Lee, Colin Lee, Xiaohui Zhao, Maria Donde |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.09.03.279919 |
| Popis: |
Hofbauer cells (HBC) are a population of macrophages found in high abundance within the stroma of the first trimester human placenta. HBC are the only fetal immune cell population within the stroma of healthy placenta. However, the functional properties of these cells are poorly described. Aligning with their predicted origin via primitive haematopoiesis, we find that HBC are transcriptionally similar to yolk sac macrophages. Phenotypically, HBC can be identified as HLA-DR-FOLR2+ macrophages. We identify a number of factors HBC secrete (including IL-8 and MMP-9) that could affect placental angiogenesis and remodelling. We determine that HBC have the capacity to play a defensive role, where they are responsive to Toll-like receptor stimulation and are microbicidal. Finally, we also identify a population of placenta-associated maternal macrophages (PAMM1a) that adhere to the placental surface and express factors, such as fibronectin, that may aid in repair.SummaryUsing transcriptomic and proteomic data, Thomas, J. et al, analyse human first trimester placental macrophages and delineate markers that identify them. They also reveal that Hofbauer cells have microbicidal capacity, providing the fetus with an additional layer of protection from certain microbes.One sentence summaryHofbauer cells are primitive placental macrophages with a unique phenotype and role in fetal defence.Non-standard abbreviationPlacental associated maternal monocytes/macrophages, PAMM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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