Synthesis of some new oxazepine compounds derived from cyanoethyl acetate and study their inhibitory activity against some pathogenic bacterial species
| Autor: | Diaa M. Najim, Khalid A. Al-badrany, Mahmood K. Saleh |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :14527-14541 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns1.8901 |
| Popis: | Involves synthesis of Schiff bases (hydrazone) by the reaction of acid hydrazide(D1) (which is prepared from the reaction of cyanoethyl acetate with hydrazine hydrate at (85%) with aromatic aldehydes to obtain compounds (D2-6) and by the reaction of compounds (D2-6) with phthalic anhydride Compounds (D7-11) are obtained, the biological activity of the prepared compounds is studied through two types of Gram-positive and Gram-negative bacteria Staph. aureus, Escherichia Coli and Compare it with one type of antibiotic (Gentamycin). The validity of the structures is confirmed by spectroscopic methods (FTIR, 1H-NMR, 13C-NMR, MASS). The disk diffusion assay technique was used to investigate the antibacterial activity in vitro against two types of bacteria: gram-positive and gram harmful bacteria. The minimum inhibitory concentration [MIC] was measured using standard medications. The findings revealed that azetidine derivatives outperformed drugs in inhibiting the growth of both gram-positive and gram-negative bacteria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|