ChemInform Abstract: Preparation and Antioxidant Activities of Phenolic Esters and Ethers of L-Ascorbic Acid

Autor:	Paul A. Seib, Lixian Gan
Rok vydání:	2010
Předmět:	Antioxidant Thiobarbituric acid medicine.medical_treatment Ether Sulfuric acid General Medicine Ascorbic acid chemistry.chemical_compound chemistry Yield (chemistry) medicine Organic chemistry Fractional crystallization (chemistry) Gallic acid
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199838246
Popis:	Esterification of L-ascorbic acid in concentrated sulfuric acid with 0.33 moles of gallic acid gave a 90% yield of a 2:5 mixture of L-ascorbyl 5- and 6-gallate esters. The 6-gallate ester (1) was purified from the 5-gallate ester (2) by fractional crystallization in 40% yield. Three other aromatic derivatives of L-ascorbic acid also were prepared. The order of antioxidant activities of the L-ascorbyl derivatives determined by thiobarbituric acid number in methyl linolenate at 37 °C was as follows: 6-gallate (1) > 6-(3′,4′ -dihydroxy)benzoate (3) = 6-(4′ -hydroxy)phenyl ether (4) >6-(4′ methoxy)phenyl ether (5).
Databáze:	OpenAIRE
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