Target Delivery of Daunorubicin to Glioblastoma by Cyclic RGD-Linked PEG-PLA Micelles

Autor:	Xingang Guan, Haibin Tong, Jun Ma, Xinqiang Guan, Xin Sun
Rok vydání:	2015
Předmět:	Materials science Polymers and Plastics medicine.diagnostic_test Daunorubicin General Chemistry medicine.disease Drug accumulation Micelle Flow cytometry Biochemistry Materials Chemistry Ceramics and Composites medicine Biophysics Cyclic RGD Cytotoxicity Ex vivo Glioblastoma medicine.drug
Zdroj:	Journal of Macromolecular Science, Part A. 52:401-406
ISSN:	1520-5738 1060-1325
DOI:	10.1080/10601325.2015.1018816
Popis:	Daunorubicin (Dau) has been widely used in the treatment of many solid tumors. However, the side effects of Dau seriously hinder its further application in clinical use. How to increase the drug accumulation in tumors and reduce the damage to normal tissues is an urgent problem to be solved. In this study, we developed c(RGDfK) decorated PEG-PLA micelles for target delivery of Dau to C6 glioblastoma cells. The enhanced uptake of cRGD decorated micelles by C6 cells were observed via CLSM and flow cytometry experiments. Moreover, the cRGD decorated micelles showed more cytotoxicity to C6 cells than undecorated micelles ex vivo. Therefore, cRGD decorated micelles represent a promising approach in improving drug accumulation for treatment of glioblastoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ff163b956c9f60c52cd7f6a347290679 https://doi.org/10.1080/10601325.2015.1018816 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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