Nutritional Regulation of Apolipoprotein Genes: Effect of Dietary Carbohydrates and Fatty Acids
| Autor: | Agnès Ribeiro, Claude Loriette, Yves Rayssiguier, Marise Mangeney, Philippe Cardot, Gilbert Bereziat, Jean Chambaz |
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| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
Regulation of gene expression Very low-density lipoprotein Apolipoprotein B biology Fatty acid metabolism Chemistry Fish oil Oleic acid chemistry.chemical_compound Biochemistry Essential fatty acid biology.protein lipids (amino acids peptides and proteins) Polyunsaturated fatty acid |
| Zdroj: | Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics ISBN: 9781468459067 |
| DOI: | 10.1007/978-1-4684-5904-3_49 |
| Popis: | The effect of nutritional factors on apolipoprotein gene expression by rat liver were studied. Dietary carbohydrates or fatty acids regulate the expression of apo E gene, by altering either gene transcription or mRNA stability. Conversely, apo AT regulation occurs at a post transcriptional level. In vivo and in vitro experiments gave contradictory results concerning apo B gene expression. The more dramatic changes in plasma lipids and apolipoproteins are obtained under dietary fish oil. Hepatocytes from fish oil-fed rats retain for several days modification in fatty acid metabolism, i.e. a shift in oleic acid channeling towards oxidation at the expense of csterification and a reduced ability to synthesize and secrete triacylglycerol. These modifications are paralleled with a decrease in the synthesis and in the secretion of apo Bs. Hepatocytes from fish oil fed rats secrete degradative forms of apo B which might result from either a sluggish VLDL synthesis and secretion or a more specific effect of n-3 long chain polyunsaturated fatty acid peroxidative products. Hepatocytes from fish oil fed rats exhibit a reduced ability to synthesize cholesterol, associated with a decrease in apo AT synthesis and secretion without any modification in apo AI mRNA. In contrast, the hepatocytes exhibit a concomitent decrease in apo E synthesis and secretion and in cellular apo E mRNA levels. |
| Databáze: | OpenAIRE |
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