Convenient synthesis of 5-aryl(alkyl)sulfanyl-1,10-phenanthrolines from 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, and their activity towards fungal β-d-glycosidases

Autor:	Vyacheslav V. Samoshin, Nataliya M. Samoshina, Irina A. Dotsenko, Matthew Curtis
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Ligand Phenanthroline Aryl Organic Chemistry Epoxide Biochemistry Chemical synthesis chemistry.chemical_compound chemistry Sulfanyl Drug Discovery Thiol Organic chemistry Alkyl
Zdroj:	Tetrahedron. 67:7470-7478
ISSN:	0040-4020
Popis:	A broad series of novel 5-aryl(alkyl)sulfanyl-1,10-phenanthrolines has been prepared by a new simple procedure: a treatment of the commercially available 5,6-epoxy-5,6-dihydro-1,10-phenanthroline with various thiols in the presence of a base. Other functional groups attached to the thiol allow a use of the products as building blocks in synthesis of versatile ligands and in functionalization of surfaces. The synthesized phenanthrolines showed a moderate ability as activators or inhibitors of fungal β-d-glucosidases and β-d-galactosidases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ff0e774662705a20fb375237e349dd68 https://doi.org/10.1016/j.tet.2011.07.058 Zobrazit plný text záznamu Full Text from ScienceDirect