Synthesis and biological activities of new heterocyclic aromatic retinoids
| Autor: | Lucien Stella, Philippe Diaz, Bruno Charpentier, S. Michel |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Bicyclic molecule Chemistry Stereochemistry Carboxylic acid Cellular differentiation Organic Chemistry Clinical Biochemistry Retinoic acid Pharmaceutical Science Biochemistry Affinities Chemical synthesis In vitro Retinoic acid receptor chemistry.chemical_compound Drug Discovery Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:2289-2294 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00405-8 |
| Popis: | A series of 3-aryl-2H-1-benzopyrancarboxylic acid derivatives was synthesized and evaluated as Retinoic Acid Receptor (RAR) agonists. By modifications of the 3-aryl group, we have obtained new retinoids exhibiting potent cellular differentiating activities and high affinities for RARs. Moreover, hydrogenation of the 2H-1-benzopyran ring led to the 3-(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-naphthalen-2-yl)-3,4-dihydro-2H-1-benzopyran-7-yl carboxylic acid, characterized by a RARs binding profile. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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