325 DEVELOPMENT OF INTESTINAL SUCRASE ACTIVITY: INTER ACTION OF THYROID AND ADRENAL HORMONES
| Autor: | T Allen Merritt, Yvonne Vaucher, Judy Grimes, Otakar Koldovsky |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases business.industry Thyroid Endogeny Intestinal sucrase activity Ileum Jejunum chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Adrenal hormones Corticosterone Internal medicine Pediatrics Perinatology and Child Health Time course medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pediatric Research. 19:165A-165A |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198504000-00355 |
| Popis: | Administration of exogenous thyroid hormones precociously increase intestinal sucrase activity (SA) in suckling rats. To differentiate the effects of thyroid and adrenal hormones on SA, intact suckling Sprague-Dawley rats were given TSH (0.5U) bid or water subcutaneously from day 14 until sacrifice on day 18. Results are shown below (x+SEM). Serum T4 and corticosterone (CS) as well as SA in the jejunum (J), mid-jejunum (MJ) and ileum (I) were all significantly increased in intact TSH treated rats. Sucklings were then adrenalectomized (ADX) on day 14 and given TSH (0.5 or 1.0U) bid or water subcutaneously until sacrifice on day 18. No significant differences in SA were found between ADX sucklings given TSH(1 or 2U/day) and ADX controls given water only. In the absence of the adrenal glands, physiologic elevation of endogenous thyroid hormones by TSH does not alter the maturational time course of intestinal sucrase activity. |
| Databáze: | OpenAIRE |
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