FEATURES OF MORPHOFUNCTIONAL REMODELLING OF RAT HEPATOCYTES AND THEIR QUANTITATIVE CHARACTERISTICS AGAINST THE GROUND OF CHRONIC ACETYLSALICYLIC ACID POISONING
| Autor: | I. Ye. Herasymyuk, M. P. Klantsa |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Clinical anatomy and operative surgery. 17:6-11 |
| ISSN: | 1993-5897 1727-0847 |
| DOI: | 10.24061/1727-0847.17.3.2018.1 |
| Popis: | According to the results of the study, it has been established that chronic acetylsalicylic acid poisoning results in severe liver disorders presented by both venous and portal blood overloaded with a reflex throughput decrease of the arterial part of the bloodstream. Prolonged venous stasis and reflex vasoconstriction of arteries lead to ischemia of the liver tissue with the development and progression of dystrophic changes in hepatocytes. With an increase in the duration of observation, there is an expansion of cell zones with signs of granular dystrophy, which pass into fields with dystrophy of hepatic cells, damage of intercellular boundaries, homogenization of cytoplasm and degradation of nuclei of hepatocytes. It was manifested quantitatively by an increase in the cross-section of hepatocytes and their nuclei with an appropriate dynamics of nuclear-cytoplasmic relations. |
| Databáze: | OpenAIRE |
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