Estimation of Erythromycin and inducible Clindamycin Resistance in Saphylococcus aureus Isolated from Clinical Cases
| Autor: | Zahid Saadoon Aziz, Amany Menam Mtsher |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Clindamycin resistance business.industry 030106 microbiology Clindamycin Erythromycin Human pathogen medicine.disease_cause Microbiology law.invention 03 medical and health sciences 030104 developmental biology Staphylococcus aureus law Intensive care medicine Pharmacology (medical) business Pharmacology Toxicology and Pharmaceutics (miscellaneous) Staphylococcus Polymerase chain reaction medicine.drug |
| Zdroj: | Research Journal of Pharmacy and Technology. 13:2920 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2020.00538.7 |
| Popis: | Staphylococcus aureus is an important human pathogen. It is one of the common of both endemic and epidemic infections acquired in hospitals which result in substantial morbidity and mortality. S.aureus causing 50% or more of hospital-acquired S.aureus infections in several countries andcould cause life-threatening infections when mucosal or cutaneous barriers are broken. This study aims to determine the Erythromycin and inducible Clindamycin phenotypic and genotypic resistance, and the estimation prevalence of Erm A gene among the identified S.aureus in Maysan Province. A total of 300 samples were taken from patients suffering from different clinical infections during a period continued from October 2018 till March 2019. The samples were routinely cultivated and confirmed by using standard laboratory techniques where (103) were identified as S.aurues. The results of Erythromycin resistance and Clindamycin were 62 (60.1%) and 41 (39.8%) respectively. While the result of D-test appeared that 12 (11.6%) were positive to D-test whilst resistance to both Erythromycin and Clindamycin (R phenotype) was 15(14.5%)and sensitivity to both Erythromycin and Clindamycin (S phenotype) was 23 (22.5%). The result of Polymerase Chain Reaction (PCR) revealed that 100 (97%) of S.aureus were carried the ErmA gene. So the study went to concluded the high rates of prevalence of Erm A gene among identified S.aureus as comparing with phenotypic results which in turn lead to reduce the chance of available treatment especially through the intensive care units. |
| Databáze: | OpenAIRE |
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