Coordinating Multiple Droplets in Planar Array Digital Microfluidic Systems
| Autor: | Srinivas Akella, Eric J. Griffith |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0209 industrial biotechnology
Engineering Microfluidics Planar array Hardware_PERFORMANCEANDRELIABILITY 02 engineering and technology computer.software_genre law.invention Physics::Fluid Dynamics 020901 industrial engineering & automation Software Artificial Intelligence law Hardware_INTEGRATEDCIRCUITS 0202 electrical engineering electronic engineering information engineering Electronic engineering Hardware_ARITHMETICANDLOGICSTRUCTURES Electrical and Electronic Engineering SIMPLE algorithm business.industry Page layout Applied Mathematics Mechanical Engineering Lab-on-a-chip Modeling and Simulation 020201 artificial intelligence & image processing Routing (electronic design automation) business computer Computer hardware |
| Zdroj: | The International Journal of Robotics Research. 24:933-949 |
| ISSN: | 1741-3176 0278-3649 |
| DOI: | 10.1177/0278364905059067 |
| Popis: | In this paper we present an approach to coordinate the motions of droplets in digital microfluidic systems, a new class of lab-on-a-chip systems for biochemical analysis. A digital microfluidic system typically consists of a planar array of cells with electrodes that control the droplets. The primary challenge in using droplet-based systems is that they require the simultaneous coordination of a potentially large number of droplets on the array as the droplets move, mix, and split. In this paper we describe a general-purpose system that uses simple algorithms and yet is versatile. First, we present a semi-automated approach to generate the array layout in terms of components. Next, we discuss simple algorithms to select destination components for the droplets and a decentralized scheme for components to route the droplets on the array. These are then combined into a reconfigurable system that has been simulated in software to perform analyses such as the DNA polymerase chain reaction. The algorithms have been able to successfully coordinate hundreds of droplets simultaneously and perform one or more chemical analyses in parallel. Because it is challenging to analytically characterize the behavior of such systems, simulation methods to detect potential system instability are proposed. |
| Databáze: | OpenAIRE |
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