In vitro drug release from porous cellulose matrices

Autor:	G. Ragnarsson, O. Camber, C. Bjerre, T. Gren
Rok vydání:	1996
Předmět:	Drug Chromatography Diffusion media_common.quotation_subject Pharmaceutical Science Dosage form chemistry.chemical_compound chemistry Chemical engineering Liberation Cellulose Solubility Porosity Dissolution media_common
Zdroj:	International Journal of Pharmaceutics. 141:53-62
ISSN:	0378-5173
DOI:	10.1016/0378-5173(96)04614-5
Popis:	Drugs of different solubilities were incorporated into porous cellulose matrices (PCMs) by solvent evaporation. The rate of release of the drugs from the PCMs was found to decrease with increasing drug concentration and decreasing drug solubility. At low or moderate drug concentrations, the release rate remained moderately high except for drugs of very low solubility. The mechanisms controlling release rate appeared to include diffusion within the matrix but may be more complex.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fef76b7ae396557df2df0a6f7ada3cf4 https://doi.org/10.1016/0378-5173(96)04614-5 Zobrazit plný text záznamu Full Text from ScienceDirect