A transdermal nicotine system: feasibility studies

Autor:	Paul M. Gargiulo, Bret Berner, Robert J. Steffens, Gerard C. Mazzenga
Rok vydání:	1992
Předmět:	integumentary system Epidermis (botany) Chemistry medicine.medical_treatment Synthetic membrane Pharmaceutical Science Absorption (skin) Pharmacology Permeation Dosage form Nicotine Membrane medicine Smoking cessation medicine.drug
Zdroj:	Journal of Controlled Release. 20:13-19
ISSN:	0168-3659
DOI:	10.1016/0168-3659(92)90134-d
Popis:	The permeation of nicotine through human epidermis in vitro, membranes, adhesives, an adhesive-membrane laminate, and the laminate with epidermis was measured. Skin irritation in rabbits was shown to depend on the driving force of nicotine in the donor phase. A transdermal nicotine system is described that provides substantial control of nicotine entry through skin by a rate-controlling membrane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::feeac418d15c7259ecc9f8ec41cae1ce https://doi.org/10.1016/0168-3659(92)90134-d Zobrazit plný text záznamu