| Popis: |
We have previously shown that the enhanced biosynthesis of renal flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) from riboflavin may be causally related to the aldosterone-mediated reabsorption of Na+. The simultaneous administration of the riboflavin analogs 7,8-dimethyl-10-formylmethyl isoalloxazine (FMI) and 7,8dimethyl-10-(2′-hydroxyethyl) isoalloxazine (HEI) diminished the conversion of riboflavin to FMN by competitively inhibiting the enzyme flavokinase (EC 2 · 7 · 1 · 26). Both analogs acted as natriuretic agents in the presence of aldosterone in a dose-dependent fashion. |
