Metal Complexes of Functionalized Sulfur-Containing Ligands. Part XIX
| Autor: | Wolfgang Weigand, Hans-Dietrich Stachel, Andreas Windt, Hermann Poschenrieder, Elisabeth Immerz-Winkler, Ralf Wünsch, Norbert Drescher |
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| Rok vydání: | 2003 |
| Předmět: |
Bicyclic molecule
Stereochemistry Organic Chemistry Ring (chemistry) Sulfur containing Biochemistry Medicinal chemistry Oxidative addition Catalysis Inorganic Chemistry Metal chemistry.chemical_compound Sulfinamide chemistry Nucleophile visual_art Drug Discovery Electrophile visual_art.visual_art_medium Physical and Theoretical Chemistry |
| Zdroj: | Helvetica Chimica Acta. 86:2471-2480 |
| ISSN: | 1522-2675 0018-019X |
| DOI: | 10.1002/hlca.200390200 |
| Popis: | The title compounds were prepared starting from the dihydropyrrolones 4–6. Nucleophilic displacement and ring closure yielded the 1H-pyrrolo[3,2-c]isothiazol-5(4H)-ones 8 and 10. The fused systems formed salts with strong acids and electrophiles (15, 16), as well as with bases. Oxidation led either to S(2)-oxides (18a, 20a) or to the corresponding bicyclic sultams (18b, 20b), depending on the reaction conditions. The sulfinamide 18a was also obtained from the known 1,2-dithiolopyrrolone S-oxide 21 by a ring-opening/ring-closure reaction sequence. O-Methylation of 8 furnished the ‘azafulvene' 17. The oxidative addition of [Pt(η2-C2H4)L2] (24a: L=Ph3P, 24b: L=1/2 dppf, 24c: L=1/2 (R,R)-diop) to 18a and 20a led to the cis-amido-sulfenato Pt complexes 25 and 26a–c, respectively. |
| Databáze: | OpenAIRE |
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