Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
| Autor: | Christopher J. Schultz, Minhee Won, Jan C. Buckner, Peter Ricci, Stephen W. Coons, Stephanie L. Pugh, Dennis E. Bullard, Harold Kim, Albert Murtha, Geoffrey R. Barger, Paul D. Brown, Minesh P. Mehta, Keith J. Stelzer, John H. Suh, Barbara Fisher, Walter J. Curran, Jean Paul Bahary, Mark R. Gilbert, Erica Hlavin Bell, David Brachman, Edward G. Shaw, Arnab Chakravarti |
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| Rok vydání: | 2016 |
| Předmět: |
Vincristine
medicine.medical_specialty Oligoastrocytoma medicine.diagnostic_test business.industry medicine.medical_treatment Combination chemotherapy General Medicine Lomustine medicine.disease Procarbazine Surgery Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Biopsy medicine Oligodendroglioma business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | New England Journal of Medicine. 374:1344-1355 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy... |
| Databáze: | OpenAIRE |
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