Transneuronal degeneration of the inferior olivary nuclei in system atrophy
| Autor: | Arnulf H. Koeppen, Robert J. Cassidy, K. D. Barron |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cerebellum
Palatal myoclonus Anatomy Biology medicine.disease Transneuronal degeneration Pathology and Forensic Medicine Cellular and Molecular Neuroscience Dentate nucleus medicine.anatomical_structure nervous system Gliosis Cerebellar cortex medicine Inferior olivary nucleus Neurology (clinical) Brainstem medicine.symptom |
| Zdroj: | Acta Neuropathologica. 47:155-158 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00717040 |
| Popis: | Hypertrophy of the inferior olivary nuclei was observed in a patient who had progressive ataxia during life but no palatal myoclonus. A definite family history could not be established. Central nervous system lesions included sweeping loss of Purkinje cells, fiber depletion of the cerebellar white matter, neuronal loss and gliosis of the dentate nuclei, necrobiosis of neurons of the substantia nigra, and dorsal column degeneration. Olivary changes included nerve cell loss, enlargement of the remaining neuronal cell bodies in the anterior folds of the inferior olivary nuclei with formation of elaborate dendritic expansion (glomeruloid structures) and neuronal vacuolation, and proliferation of astrocytes. In contrast, the dorsal folds of the inferior olivary nuclei and medial and dorsal accessory olives revealed retrograde atrophy of neurons. Neither palatal myoclonus nor olivary hypertrophy are common accompaniments of hereditary and nonhereditary system atrophies of cerebellum and brainstem. |
| Databáze: | OpenAIRE |
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