Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II)

Autor:	Nizam U. Khan, S.M. Hadi, Aparna Jain, Nazneen Parveen, J.H. Parish, Mercedes Martín
Rok vydání:	1999
Předmět:	Pharmacology chemistry.chemical_classification Stereochemistry Chemistry fungi Mutagenesis Flavonoid food and beverages Cleavage (embryo) carbohydrates (lipids) chemistry.chemical_compound Dna cleavage heterocyclic compounds Fragmentation (cell biology) DNA Bond cleavage
Zdroj:	Phytotherapy Research. 13:609-612
ISSN:	1099-1573 0951-418X
DOI:	10.1002/(sici)1099-1573(199911)13:7<609::aid-ptr566>3.0.co;2-i
Popis:	DNA strand scission reactions of flavonoids in the presence of Cu(II) have been extended by using flavonoids with a variety of patterns of hydroxyl substitution. In particular we have examined for the first time a flavonoid (7,8-dihydroxyflavone) that lacks the possibility of forming a complex involving the oxygen at position 4. By comparing the reactivities of several flavonoids, including data from the literature, we draw generalizations for the correlation of structure and activity and present evidence for at least three different modes of action of flavonoids as genotoxic agents.
Databáze:	OpenAIRE
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