| Autor: |
Zahra Hasan, Kiran Iqbal Masood, Shama Qaiser, Erum Khan, Areeba Hussain, Zara Ghous, Unab Khan, Imran Hassan, Maliha Yameen, Haris Ali Memon, Shiza Ali, Sadaf Balouch, Muhammad Imran Nasir, Muhammad Farrukh Qazi, Marc Veldhoen, J Pedro Simas, Zulfiqar A Bhutta, Syed Faisal Mahmood, Rabia Hussain, Kulsoom Ghias |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1763604/v1 |
| Popis: |
Introduction Sinopharm (BBIBP-CorV) inactivated virus vaccination for COVID-19 has been administered widely in Pakistan. We investigated the dynamics of BBIBP-CorV -induced antibody responses over a 24 week period in a region with a high seroprevalence. Methods Study subjects (n = 312) were followed up over a 24-week period between May and August 2021. Sera were tested for IgG antibodies to spike and the receptor binding domain (RBD). Results Study subjects were 62% female. Twenty-two percent had a prior history of COVID-19. At 4-, 8- 16- and 24-weeks post-vaccination, the rate of IgG antibodies positive to spike was 57%, 87%, 66% and 90% of individuals, compared with to RBD which was 48%, 62%, 68% and 85% of subjects, respectively,. IgG to spike and RBD showed a positive correlation at each interval (rho > 0.6, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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