Inhibitory effects of aspirin and indomethacin on the biosynthesis of PGE2 and PGF2α
| Autor: | Marc Julius, A. Douglas Bender, Joseph W. Horodniak, J.E. Zarembo |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Aspirin
Biophysics Prostaglandin Cell Biology Pharmacology Inhibitory postsynaptic potential Biochemistry chemistry.chemical_compound Seminal vesicle medicine.anatomical_structure Biosynthesis chemistry Statistical analyses medicine lipids (amino acids peptides and proteins) Molecular Biology Inhibitory effect medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 57:539-545 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(74)90966-8 |
| Popis: | A gas-liquid chromatography system has been used to study the effects of indomethacin and aspirin on the biosynthesis of PGE2 and PGF2α by the prostaglandin synthetase system of bovine seminal vesicle. Both compounds were found to inhibit the production of PGE2 and PGF2α. However, based on statistical analyses, the inhibitory effect of indomethacin was found to be non-selective while aspirin produced statistically significant preferential inhibition of PGE2 over PGF2α. |
| Databáze: | OpenAIRE |
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