A randomized controlled trial of cultured keratinocyte allografts for chronic venous ulcers

Autor:	A Withers, P Duhra, A Ilchyshyn, I. M. Cheshire, A. Blight, E. M. Mountford
Rok vydání:	1992
Předmět:	medicine.medical_specialty business.industry Significant difference Pain relief Single application Dermatology Placebo Surgery law.invention medicine.anatomical_structure Randomized controlled trial law Healing rate medicine Wound healing Keratinocyte business
Zdroj:	Journal of Dermatological Treatment. 3:189-191
ISSN:	1471-1753 0954-6634
DOI:	10.3109/09546639209088721
Popis:	The efficacy of cultured keratinocyte allografts on the healing rate and pain relief of 30 small and medium-sized chronic venous leg ulcers was assessed in a prospective, randomized, placebo-controlled study. Measurements of surface area, ulcer bed appearance and pain severity were made at fortnightly intervals for 6 weeks. There was significant healing of ulcers in both the allografted and control groups (P = 0.001), but there was no significant difference between the two groups (P>0.05). There was also no significant difference between the two treatments in the amount of pain relief obtained. Thus, a single application of cultured keratinocyte allografts to chronic venous ulcers offered no advantage for wound healing or pain relief as compared with placebo. The low efficacy and the expense of cultivating and storing allografts does not allow a single application of cultured allografts to be recommended at present as a routine treatment for venous leg ulcers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe924fff6b644c64d62924185d021f09 https://doi.org/10.3109/09546639209088721 Zobrazit plný text záznamu