Enantioselective Morita–Baylis–Hillman Reaction of Acrylates with Nitrobenzaldehydes Promoted by the Bifunctional Ferrocene-Based Phosphinothiourea Organocatalysts
| Autor: | Yang Lei, Chuang Li, Shao-Yu Guan, Hui Chen, Weiping Chen, Ru Jiang, Peng-Fei Ma |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences Aldehyde Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Ferrocene Thiourea Organic chemistry Moiety Baylis–Hillman reaction Bifunctional |
| Zdroj: | Catalysis Letters. 146:1429-1434 |
| ISSN: | 1572-879X 1011-372X |
| Popis: | A series of ferrocene-based bifunctional phosphinothiourea organocatalysts were synthesized and applied to the enantioselective Morita–Baylis–Hillman reaction of acrylates with nitrobenzaldehydes, giving the desired products in up to 99.7 % ee. The strong electron-withdrawing effect of nitro group and hydrogen bonding interactions between the thiourea moiety of catalyst and aldehyde might be crucial during the enantio-controlling process. |
| Databáze: | OpenAIRE |
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