Revised upper limb module for spinal muscular atrophy: 12 month changes
| Autor: | Jacqueline Montes, Eugenio Mercuri, Darryl C. De Vivo, Basil T. Darras, Francesca Bovis, Francesco Muntoni, Maria Pia Sormani, John W. Day, Marion Main, Mariacristina Scoto, Roberto De Sanctis, Maria Carmela Pera, Amy Pasternak, Sally Dunaway Young, Robert Muni Lofra, Marika Pane, Volker Straub, Richard S. Finkel, Giorgia Coratti, Danielle Ramsey, Tina Duong, Allan M. Glanzman, Elena S. Mazzone, Anna Mayhew |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology business.industry Spinal muscular atrophy 030105 genetics & heredity medicine.disease SMA 03 medical and health sciences Cellular and Molecular Neuroscience Spinal Muscular Atrophy Type 2 0302 clinical medicine Muscle nerve medicine.anatomical_structure Physical medicine and rehabilitation Physiology (medical) Functional abilities medicine Upper limb In patient Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 59:426-430 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.26419 |
| Popis: | Introduction The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. Methods Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. Results The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. Discussion Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019. |
| Databáze: | OpenAIRE |
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