Resistant starch significantly alters gut microbiota and liver metabolome in mice fed a high fat diet (822.13)
| Autor: | Tamara N. Dunn, Michael J. Keenan, Roy J. Martin, Sean H. Adams, Dorothy A. Kieffer, Eun Ji Kim, Maria L. Marco |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Creatinine food.ingredient Firmicutes Bacteroidetes Biology Gut flora biology.organism_classification digestive system Biochemistry Amino acid chemistry.chemical_compound Endocrinology food chemistry Internal medicine Genetics medicine Metabolome Microbiome Resistant starch Molecular Biology Biotechnology |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.28.1_supplement.822.13 |
| Popis: | Resistant starch (RS) is a fermentable dietary fiber shown to alter gut hormones and modify the gut microbiome. Because RS impacts the gut microbiota, we hypothesize that RS changes gut-derived signals reaching the liver by altering the gut microbiota and, in turn altering liver metabolism. To assess the effects of RS on the liver metabolome under obesogenic conditions, male C57Bl/6J mice were fed a 45% fat diet for 10 weeks supplemented with type 2 RS (10% by wt) or maltodextrin (n=15/group). As expected, increased cecal weights (by 55%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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