An unprecedented Ag–pipemidic acid complex with helical structure: Synthesis, structure and interaction with CT-DNA

Autor:	Hong-Bin Wu, Er-Lin Zhang, Meng-Ting Li, Jingquan Sha, Tao-Ye Zheng, Jing-Wen Sun
Rok vydání:	2013
Předmět:	Stereochemistry Organic Chemistry Pipemidic acid Crystal structure Binding constant Analytical Chemistry Ion Inorganic Chemistry chemistry.chemical_compound Crystallography chemistry medicine Molecule Binding site Ethidium bromide Spectroscopy DNA medicine.drug
Zdroj:	Journal of Molecular Structure. 1045:29-34
ISSN:	0022-2860
Popis:	A new Ag–pipemidic acid complex with helical structure has been prepared and structurally characterized by routine technique. Single-crystal X-ray diffraction analysis shows that there are the left- and right-handed helical chains constructed by Ag ions and PPA drugs along the b direction. And two types of helical chains are connected into 2D layer by sharing pseudo-tetra-nuclear clusters, which are stabilized by PPA-1 molecules as scaffolds. UV study of the interaction of the complex with CT-DNA shows that the title complex can bind to the CT-DNA and exhibits the higher binding constant ( K b ) than free HPPA drugs. Additionally, its competitive study with ethidium bromide and the relatively high K SV value also indicates that complex can bind to DNA for the intercalative binding sites.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe5cc907398527fa10984df51193b9c0 https://doi.org/10.1016/j.molstruc.2013.04.028 Zobrazit plný text záznamu Full Text from ScienceDirect