Solvent-Free Synthesis and Antibacterial Evaluation of Novel Coumarin Sulfonamides
| Autor: | Ahmad Reza Massah, Neda Mostajeran, Hamid Aliyan, Farzaneh Amin Arshad |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Solvent free 010405 organic chemistry Chemistry 010402 general chemistry Chlorosulfonic acid medicine.disease_cause Coumarin 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Staphylococcus aureus bacteria Elemental analysis Yield (chemistry) Drug Discovery Proton NMR medicine Organic chemistry heterocyclic compounds Escherichia coli |
| Zdroj: | Pharmaceutical Chemistry Journal. 52:1-7 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | A series of new coumarin-6-sulfonamides have been synthesized as potential antibacterial agents. The reaction of coumarin with chlorosulfonic acid was found to yield the corresponding coumarin sulfonyl chloride (1). In the next step, coumarin sulfonyl chloride, was reacted with various amines in the presence of K2CO3 under solvent-free conditions to produce coumarine sulfonamides (2a – 2s) in good to excellent yields. The chemical structures of the products were elucidated by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. All the synthesized compounds have been screened for their in vitro anti-bacterial activities against Escherichia coli and Staphylococcus aureus bacteria. |
| Databáze: | OpenAIRE |
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