Visualization of cancer-related chemical components in mouse pancreas tissue by tapping-mode scanning probe electrospray ionization mass spectrometry

Autor:	Masafumi Kyogaku, Shuya Satoh, Yoichi Otsuka, Junpei Naito, Hiroyuki Hashimoto
Rok vydání:	2015
Předmět:	Biological specimen Chromatography Chemistry Electrospray ionization Molecular imaging Biomarker discovery Spectroscopy Mass spectrometry imaging Ion Visualization Ambient ionization
Zdroj:	Journal of Mass Spectrometry. 50:1157-1162
ISSN:	1076-5174
DOI:	10.1002/jms.3634
Popis:	Mass spectrometry imaging is an informative approach for the comprehensive analysis of multiple components inside biological specimens. We used novel tapping-mode scanning probe electrospray ionization mass spectrometry method to visualize cancer-related chemical components in the mouse pancreas tissue section at a sampling pitch of 100 µm. Positive ion mode measurements from m/z 100 to 1500 resulted in the visualization of multiple components that are tentatively assigned as polyamines, lipids and proteins. Their signal intensities inside the cancerous and the non-cancerous regions were found to be significantly different by the two-sample t-test.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe4b4474c7ef5257bb0502a978772eb9 https://doi.org/10.1002/jms.3634 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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