ChemInform Abstract: The Solution Phase Synthesis of Diketopiperazine Libraries via the Ugi Reaction: Novel Application of Armstrong′s Convertible Isonitrile

Autor:	Francis A. Volz, Christopher J. Burns, Matthew M. Morrissette, Christopher Hulme
Rok vydání:	2010
Předmět:	Nucleophile Chemistry Ugi reaction General Medicine Combinatorial chemistry Solution phase Solution phase synthesis
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a ‘3-step, 1-pot’ procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an ‘internal nucleophile’ approach for diketopiperazine formation is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe49d9c42bda7e6657e7ec7937220492 https://doi.org/10.1002/chin.199822110 Zobrazit plný text záznamu Plný text