Associations Between the Phosphatidylethanol Alcohol Biomarker and Self‐Reported Alcohol Use in a Sample of HIV ‐Infected Outpatient Drinkers in Western Kenya
| Autor: | Hana Lee, John E. Sidle, Benson N. Gakinya, Michelle P. Loxley, Stephen A. Maisto, Steve Martino, Debra A. Klein, Joyce B. Baliddawa, Alfred Keter, Kathryn L. Schlaudt, Michael M. Mwaniki, Rebecca K. Papas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Human immunodeficiency virus (HIV) Psychological intervention Medicine (miscellaneous) Alcohol Toxicology medicine.disease_cause law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Hiv infected Environmental health medicine 030212 general & internal medicine Psychiatry business.industry Psychiatry and Mental health chemistry Biomarker (medicine) Phosphatidylethanol business 030217 neurology & neurosurgery Blood drawing |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 40:1779-1787 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.13132 |
| Popis: | BACKGROUND To counteract the syndemics of HIV and alcohol in Sub-Saharan Africa, international collaborations have developed interventions to reduce alcohol consumption. Reliable and accurate methods are needed to estimate alcohol use outcomes. A direct alcohol biomarker called phosphatidylethanol (PEth) has been shown to validate heavy, daily drinking, but the literature indicates mixed results for moderate and nondaily drinkers, including among HIV-infected populations. This study examined the associations of the PEth biomarker with self-report alcohol use at 2 time points in 127 HIV-infected outpatient drinkers in western Kenya. METHODS Participants were consecutively enrolled in a randomized clinical trial to test the efficacy of a behavioral intervention to reduce alcohol use in Eldoret, Kenya. They endorsed current alcohol use, and a minimum score of 3 on the Alcohol Use Disorders Identification Test-Consumption or consuming ≥6 drinks per occasion at least monthly in the past year. Study interviews and blood draws were conducted at baseline and at 3 months post treatment from July 2012 through September 2013. Alcohol use was assessed using the Timeline Followback questionnaire. Blood samples were analyzed for the presence of the PEth biomarker and were compared to self-reported alcohol use. We also conducted semistructured interviews with 14 study completers in February through March 2014. RESULTS Baseline data indicated an average of moderate-heavy alcohol use: 50% drinking days and a median of 4.5 drinks per drinking day. At baseline, 46% of women (31 of 67) and 8% of men (5 of 60) tested negative for PEth (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text