Die Surfactantproteine A und D: Wesentliche Faktoren des pulmonalen Abwehrsystems

Autor:	Speer Cp, Kramer Bw
Rok vydání:	2003
Předmět:	Vernix caseosa Innate immune system Immune system Maternity and Midwifery Pediatrics Perinatology and Child Health Obstetrics and Gynecology Collectin Chemotaxis Pulmonary surfactant-associated protein B Biology Acquired immune system Microbiology Pulmonary Surfactant-Associated Protein A
Zdroj:	Zeitschrift für Geburtshilfe und Neonatologie. 207:41-47
ISSN:	1439-1651 0948-2393
DOI:	10.1055/s-2003-39152
Popis:	Surfactant proteins (SP) A and D play a key role in pulmonary host defense of preterm and term newborns. SP-A and SP-D have structural elements of both collagens and lectins, for which they are called "collectins". SP-A and SP-D coordinate the innate and adaptive immune response in the lung and convey protection against infection in amniotic fluid and vernix caseosa. They are pattern-recognizing molecules of the innate immune system that are involved in binding, agglutination of pathogens, chemotaxis of neutrophils, phagocytosis of pathogens, and production of reactive oxygen species. In addition, SP-A and SP-D interact with the adaptive immune system by reducing interleukin-2 production and T lymphocyte proliferation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe430c923989c444f502d83de45c387a https://doi.org/10.1055/s-2003-39152 Zobrazit plný text záznamu