Nitrate tolerance and the links with endothelial dysfunction and oxidative stress
| Autor: | Katherine E. Fayers, Michael H. Cummings, David W Laight, Kenneth M Shaw |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
medicine.medical_specialty Antioxidant Arginine Superoxide medicine.medical_treatment Vasodilation medicine.disease medicine.disease_cause Cell biology Nitric oxide chemistry.chemical_compound Endocrinology chemistry Nitrate Internal medicine medicine Pharmacology (medical) Endothelial dysfunction Oxidative stress |
| Zdroj: | British Journal of Clinical Pharmacology. 56:620-628 |
| ISSN: | 0306-5251 |
| DOI: | 10.1046/j.1365-2125.2003.01946.x |
| Popis: | Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text