Role of 3-D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma
| Autor: | Hatsue Fujino, Yohji Honda, Takuji Yamagami, Hiroshi Aikata, Tomoki Kimura, Yoshiiku Kawakami, Masahiro Kenjo, Hiromi Kan, Kazuo Awai, Masataka Tsuge, Rika Yoshimatsu, Shoichi Takahashi, Kazuaki Chayama, Yasushi Nagata, Tomokazu Kawaoka, Hideyuki Hyogo, Tomoki Kobayashi, Daisuke Miyaki, Akira Hiramatsu, Noriaki Naeshiro, Michio Imamura, Takayuki Fukuhara |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Hepatology Performance status business.industry medicine.medical_treatment Hazard ratio Retrospective cohort study medicine.disease Thrombosis Gastroenterology Confidence interval Radiation therapy Infectious Diseases Internal medicine Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Medicine Radiology business |
| Zdroj: | Hepatology Research. 45:607-617 |
| ISSN: | 1386-6346 |
| DOI: | 10.1111/hepr.12392 |
| Popis: | Aim To evaluate the response, survival and safety on 3-D conformal radiotherapy (3D-CRT) for major portal vein tumor thrombosis (PVTT) combined with hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC). Methods In this retrospective study, 83 advanced HCC patients treated with HAIC who met the following criteria were enrolled: (i) PVTT of the main trunk or first branch of the portal vein; (ii) no extrahepatic metastasis; (iii) Child–Pugh score of 5–7; (iv) performance status of 0 or 1; and (v) no history of sorafenib treatment. The response, overall survival (OS), time to treatment failure (TTF), post-progression survival (PPS) and safety were compared between HAIC combined with 3D-CRT for PVTT (RT group, n = 41) and HAIC alone (non-RT group, n = 42). Results The objective response of PVTT was significantly higher in the RT group (56.1%) than in the non-RT group (33.3%), while that of intrahepatic tumor and OS were not significantly different between groups. Median OS, TTF and PPS were significantly longer in the RT group than in the non-RT group (8.6 and 5.0 months, 5.0 and 2.7 months, and 5.3 and 1.5 months, respectively) among intrahepatic tumor non-responders to HAIC, whereas those were not significantly different between groups among intrahepatic tumor responders to HAIC. By multivariate analysis, the combination of 3D-CRT with HAIC was an independent contributing factor for OS (hazard ratio, 3.2; 95% confidence interval, 1.692–6.021; P |
| Databáze: | OpenAIRE |
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