Anti-inflammatory quinolizidine alkaloids from the aerial parts of Sophora tonkinensis

Autor:	Dan Liu, Rui-Rong Ye, Zhi-Jun Zhang, Rong-Tao Li, Xuan-Qin Chen, Yuan-Ya Zhang
Rok vydání:	2021
Předmět:	Quinolizidine Traditional medicine biology medicine.drug_class Sophora tonkinensis Plant Science biology.organism_classification Biochemistry Anti-inflammatory chemistry.chemical_compound chemistry medicine No production Agronomy and Crop Science Biotechnology
Zdroj:	Phytochemistry Letters. 45:121-125
ISSN:	1874-3900
Popis:	Seventeen quinolizidine alkaloids, including two new ones, 5-hydoxy-7,11-dehydromatrine (1) and 11-hydroxylupanine (2), were isolated from the aerial parts of Sophora tonkinensis. The structures of the isolates were elucidated using 1D and 2D NMR analyses, as well as HR-ESI-MS spectroscopic data. The anti-inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) were evaluated. Compounds 3, 4, 13, and 14 were shown to have moderate anti-inflammatory effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe301eaef799d260988e25f5efdf4e1d https://doi.org/10.1016/j.phytol.2021.08.010 Zobrazit plný text záznamu Full Text from ScienceDirect