New synthesis of oxcarbazepine via remote metalation of protected N-o-tolyl-anthranilamide derivatives

Autor:	Olivier Lohse, Ulrich Beutler, Peter Fünfschilling, Pascal Furet, Julien France†, Daniel Kaufmann, Gerhard Penn, Werner Zaugg
Rok vydání:	2001
Předmět:	Metalation Chemistry organic chemicals Organic Chemistry Antiepileptic drug Biochemistry Medicinal chemistry Coupling reaction chemistry.chemical_compound Drug Discovery medicine Urea Amine gas treating Oxcarbazepine medicine.drug
Zdroj:	Tetrahedron Letters. 42:385-389
ISSN:	0040-4039
Popis:	Benzyl and allyl protected N-o-tolyl-anthranilamides were efficiently prepared by Buchwald–Hartwig C–N cross coupling reactions, followed by protection of the amino group. Under directed remote metalation conditions, protected dibenzoazepinones were obtained in good yields. Deprotection of the amine and conversion to an urea furnished a new and efficient synthesis of the antiepileptic drug Trileptal®.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe2ea08f5440790c4a5c5f7875f917e4 https://doi.org/10.1016/s0040-4039(00)01981-x Zobrazit plný text záznamu Full Text from ScienceDirect