Comparison of diagnostics of bacterial vaginosis according to clinical signs with results of laboratory investigations
| Autor: | Olga V. Budilovskaya, Nadezhda E. Vorobyova, Alexander E. Gushchin, Elena V. Rybina, Elena V. Shipitsina, Anna A. Krysanova, Tatyana A. Khusnutdinova, Olga Sergeyevna Ryzhkova, Alevtina Savicheva |
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| Rok vydání: | 2016 |
| Předmět: |
Vaginal discharge
Gynecology medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology medicine.disease Clinical Practice 03 medical and health sciences 0302 clinical medicine medicine In patient 030212 general & internal medicine medicine.symptom Bacterial vaginosis business |
| Zdroj: | Journal of obstetrics and women's diseases. 65:76-82 |
| ISSN: | 1683-9366 1684-0461 |
| DOI: | 10.17816/jowd65476-82 |
| Popis: | Introduction. Bacterial vaginosis (BV) is associated with a number of reproductive health disorders, therefore timely and accurate diagnosis of this condition is exceedingly important. Objective. Comparison of effectiveness of clinical and laboratory diagnostics of BV in women with vaginal discharge. Material and methods. In total, 318 patients addressing gynecological clinics with complaints about vaginal discharge participated in the study. Clinical diagnostics of BV was performed in the clinics participating in patient enrollment in accordance with their clinical practice. For laboratory diagnostics, microscopy of Gram stained smears according to the Nugent method and quantitative real-time PCR were used. Sensitivity and specificity of clinical diagnostics of BV and the molecular method were evaluated using the Nugent method as reference standard. Results. With the Nugent method, BV was diagnosed in 27% of women, with real-time PCR — in 37% of women. Using clinical signs of BV, the condition was diagnosed in 91% women. Sensitivity and specificity of the real-time PCR were 97% and 87%, respectively. Sensitivity of clinical diagnostics was 100%, but specificity was only 17%. Conclusions. Diagnostics of BV based only on the presence of vaginal discharge leads to false positive results and requires laboratory confirmation. The molecular method has a high sensitivity and satisfactory specificity for BV diagnosis and can be used as an alternative to the Nugent method. |
| Databáze: | OpenAIRE |
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