Facile synthesis and coating of aqueous antifouling polymers for inhibiting pathogenic bacterial adhesion on medical devices
| Autor: | Yoonhee Na, Daekyung Sung, Hyemi Seo, Won Il Choi, Jiseob Woo, Sujin Choi, Sunghyun Kim, Min Hee Park |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Materials science General Chemical Engineering Organic Chemistry Biofilm 02 engineering and technology Polymer Adhesion engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Biofouling Bacterial colonization chemistry Coating Materials Chemistry engineering 0210 nano-technology Healthcare providers |
| Zdroj: | Progress in Organic Coatings. 147:105772 |
| ISSN: | 0300-9440 |
| DOI: | 10.1016/j.porgcoat.2020.105772 |
| Popis: | Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. Thus, there is an urgent need for novel modification of antibiofilm surfaces on polymeric medical devices to inhibit pathogenic bacterial adhesion. Herein, we describe the development of water-soluble, antifouling polymers (APs) containing benzene moieties capable of anchoring to hydrophobic surfaces and hydrophilic poly (ethylene) glycol and carboxyl groups to inhibit pathogenic bacterial adhesion on polymeric medical devices. We found that the optimized APs could be facilely and controllably synthesized on and modify the surfaces of commercial hydrophobic substrates in aqueous solution, with the resulting polymer-coated surfaces capable of efficiently preventing pathogenic bacterial adhesion and subsequent bacterial colonization as precursors to biofilm formation. These results suggest the potential efficacy of the developed and optimized polymers for use as an antibiofilm platform to inhibit healthcare-associated infections on various polymer-based medical devices. |
| Databáze: | OpenAIRE |
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