Association of polymorphism of angiotensin-converting enzyme gene I/D and D442G cholesterol ester transfer protein gene with risk factors for atherosclerosis among elderly and senile patients with coronary heart disease in the republic of Sakha (Yakutia)

Autor: E. K. Popova, A. L. Ariev, L. S. Kozina, L. V. Grigorieva, N. S. Arkhipova
Rok vydání: 2013
Předmět:
Zdroj: Advances in Gerontology. 3:277-281
ISSN: 2079-0589
2079-0570
DOI: 10.1134/s2079057013040024
Popis: A comparative analysis was performed for frequency distribution of I/D polymorphism of angiotensin-converting enzyme (ACE) gene and D442G polymorphism of cholesterol ester transfer protein (CETP) gene in elderly and senile patients and long-lived patients with CHD with regard to ethnicity, age, and gender. The frequency of ACE*I/*I genotype reduces with age; the tendency towards increased proportion of ACE*D/*D genotype was observed. During the comparative analysis of ACE*D/*D and ACE*D/*I genotypes, gender differences were found in frequency of homozygous ACE*D/*D genotype. The carriers of ACE*D/D genotype were identified significantly more often among men than among women. Among all patients and especially among Yakuts, left ventricular hypertrophy confirmed by Sokolov-Lyon index for ECG was observed significantly more often in carriers of ACE*I/*I genotype. During the study of D442G polymorphism of CETP gene, the carriers of CETP*D/*G genotype were identified significantly more often among Yakuts than among nonindigenous individuals. During the comparison of frequencies of I/D polymorphism of the ACE gene, significant differences were observed with respect to body mass index (BMI) and blood lipids. In comparison of CETP*D/*D and CETP*D/*G genotypes, no significant association with CHD risk factor was found.
Databáze: OpenAIRE
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