Organophosphorus compounds. II: Synthesis and cholinesterase inhibition of a series of alkyl and cycloalkyl methylphosphonofluoridothionates

Autor:	A. J. J. Ooms, H. L. Boter
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Difluoride Organic chemistry Ether Alcohol General Chemistry Benzene Acetylcholinesterase Triethylamine Alkyl Butyrylcholinesterase
Zdroj:	Recueil des Travaux Chimiques des Pays-Bas. 85:21-30
ISSN:	0165-0513
DOI:	10.1002/recl.19660850104
Popis:	A number of alkyl and cycloalkyl methylphosphonofluoridothionates were prepared by treatment of methylphosphonothioic difluoride with a mixture of one mole equivalent each of the appropriate alcohol and triethylamine in ether or benzene medium. Reaction velocities of the irreversible inhibition of acetylcholinesterase and butyrylcholinesterase were determined and compared with those of the corresponding phosphonofluoridates. A convenient method for the preparation of methylphosphonothioic difluoride is given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe0746b35164e7347f878b8350b12874 https://doi.org/10.1002/recl.19660850104 Zobrazit plný text záznamu