Influence of Vitamin K intake on INR and Anticoagulation in outpatients taking Warfarin
| Autor: | Norisca Aliza Putriana, Taofik Rusdiana, Tina Rostinawati, Mohammad Rizki Akbar |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Research Journal of Pharmacy and Technology. :4851-4856 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.52711/0974-360x.2022.00815 |
| Popis: | Warfarin is a type of vitamin K antagonist anticoagulant used to thromboembolic prevention and its maintenance dose differs significantly among patients. Moreover, the factor influencing the dose calculation is known as genetic polymorphism, while the influence of vitamin K intake while the effect of vitamin K intake is still a matter of debate. This study aims to provide an overview of several studies on the effect of vitamin K intake on the stability of the PT-INR value and anticoagulation in warfarin therapy patients. A study was conducted on the effect of vitamin K intake on the PT-INR value stability and anticoagulation in warfarin therapy patients. One study showed that there was no significant correlation between vitamin K usual intake and the anticoagulant effect, while in another, it was found that the stability of this effect is achievable with adequate amounts of the vitamin intake. Furthermore, another study showed that the anticoagulant effect is more stable in patients with excessive vitamin K intake on long-term warfarin use. However, other study showed that INR values will stabilize if vitamin K intake is relatively low. The results from various studies were different, therefore, there is a debate regarding the influence of vitamin K intake on the PT-INR value and anticoagulation. |
| Databáze: | OpenAIRE |
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