Cutting Edge: Defective Aerobic Glycolysis Defines the Distinct Effector Function in Antigen-Activated CD8+ Recent Thymic Emigrants
| Autor: | Cody A. Cunningham, Pamela J. Fink, Tessa Bergsbaken |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Naive T cell medicine.medical_treatment T cell Cellular differentiation Immunology Recent Thymic Emigrant mTORC1 Biology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine medicine.anatomical_structure Anaerobic glycolysis medicine Immunology and Allergy CD8 030215 immunology |
| Zdroj: | The Journal of Immunology. 198:4575-4580 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1700465 |
| Popis: | Recent thymic emigrants (RTEs) are the youngest peripheral T cells that have completed thymic selection and egress to the lymphoid periphery. RTEs are functionally distinct from their more mature but still naive T cell counterparts, because they exhibit dampened proliferation and reduced cytokine production upon activation. In this article, we show that, compared with more mature but still naive T cells, RTEs are impaired in their ability to perform aerobic glycolysis following activation. Impaired metabolism underlies the reduced IFN-γ production observed in activated RTEs. This failure to undergo Ag-induced aerobic glycolysis is caused by reduced mTORC1 activity and diminished Myc induction in RTEs. Critically, exogenous IL-2 restores Myc expression in RTEs, driving aerobic glycolysis and IFN-γ production to the level of mature T cells. These results reveal a previously unknown metabolic component to postthymic T cell maturation. |
| Databáze: | OpenAIRE |
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