Disseminated Intravascular Coagulation and Acute Renal Failure

Autor:	Cucuianu M, Crîsnic I, M Manasia, G Uza
Rok vydání:	1971
Předmět:	Disseminated intravascular coagulation medicine.medical_specialty Pregnancy business.industry Hematology Abortion medicine.disease Gastroenterology Platelet adhesiveness Internal medicine Medicine Platelet business Blood coagulation test
Zdroj:	Thrombosis and Haemostasis. 26:332-340
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1653681
Popis:	SummaryStarting from a hypothesis according to which disseminated intravascular coagulation might be an intermediary mechanism in the production of acute renal failure, investigations were made in 94 cases of anuria of different etiology, in order to detect signs of a consumption coagulopathy. After an average lapse of time of 48 h since the onset of anuria, the most frequently encountered hemostatic defect was a decreased platelet adhesiveness. In vitro experiments and clinical observations suggest that in the early stage of acute renal failure caused by a septic abortion, deficient platelet adhesiveness is due, mainly to platelet damage caused by intravascular coagulation or by bacterial toxins and not by the retention of metabolites. Euglobulin lysis time was prolonged, but a significant decrease of the plasminogen level indicates that an activation of fibrinolysis might have occured in the evolution of the process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fdf360b948d442f797b7ec7308d21aac https://doi.org/10.1055/s-0038-1653681 Zobrazit plný text záznamu