Apoptosis and proliferation of tumor cells in locally advanced cervical cancer after neoadjuvant intraarterial chemotherapy
| Autor: | Xue-qiong Zhu, Ying Zhang, Tian-fu Yue, Jing Hui, De-hua Wang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Oncology
Cervical cancer Cisplatin Cancer Research medicine.medical_specialty Chemotherapy Proliferation index business.industry medicine.medical_treatment medicine.disease Radiation therapy Apoptosis medicine.artery Internal medicine Immunohistochemistry Medicine business Uterine artery medicine.drug |
| Zdroj: | Chinese Journal of Cancer Research. 15:227-231 |
| ISSN: | 1993-0631 1000-9604 |
| Popis: | Objective: Through observing the clinical response to neoadjuvant intraarterial chemotherapy in locally advanced cervical cancer and investigating the changes of p53 protein expression, proliferation and apoptosis of tumor cells after chemotherapy, to study the relationship between biological markers and chemotherapeutic response. Methods: 20 women with locally advanced squamous cervical cancer received consecutive infusion chemotherapy of five days of cisplatin and adriamycin via the superselective uterine artery. The response to chemotherapy was evaluated by gynecologic examination and ultrasonography 3 weeks after chemotherapy. The changes of apoptotic index (AI), proliferation index (PI) and p53 expression of tumor cells were detected by immunohistochemical technique. Results: The clinical response rate of locally advanced squamous cervical cancer to uterine artery infusion chemotherapy was 70%. No change of PI was found 3 weeks after treatment, but AI significantly increased from 2.79±0.76 to 4.29±1.13 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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