Diversity-Oriented Synthesis of Spirooxindoles Using Surface-Modified TiO2 Nanoparticles as Heterogeneous Acid Catalyst
| Autor: | Kanchan Verma, Yogesh Kumar Tailor, Ram Gopal, Mahendra Kumar, Sarita Khandelwal |
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| Rok vydání: | 2017 |
| Předmět: |
Pictet–Spengler reaction
010405 organic chemistry Chemistry Isocyanide Surface modified Tio2 nanoparticles Nanotechnology General Chemistry 010402 general chemistry Heterogeneous catalysis 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Atom economy Reusability |
| Zdroj: | ChemistrySelect. 2:5933-5941 |
| ISSN: | 2365-6549 |
| Popis: | An efficient and diversity oriented synthetic protocol has been presented to synthesize spirooxindoles using isocyanide based multicomponent reaction in the presence of surface modified TiO2 nanoparticles as recyclable and reusable heterogeneous acid catalyst. This convergent synthetic protocol incorporates structural complexity and molecular diversity in molecular structures with atom economy, synthetic efficiency and operational simplicity in a time and cost-effective manner. The recyclability and reusability of the catalyst make the present synthetic protocol economically viable for industrial processes. |
| Databáze: | OpenAIRE |
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