| Autor: | Kaneto Uekama, Tetsumi Irie, Josef Pitha, Diane J. Lamb, Larry M. Mallis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Cyclodextrin Organic Chemistry technology industry and agriculture Pharmaceutical Science Mass spectrometry Ion Characterization (materials science) Amorphous solid carbohydrates (lipids) Matrix (chemical analysis) chemistry.chemical_compound chemistry Pyridine polycyclic compounds Molecular Medicine Organic chemistry Pharmacology (medical) Sulfate Biotechnology Nuclear chemistry |
| Zdroj: | Pharmaceutical Research. :1151-1154 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1015854402122 |
| Popis: | Alpha- and beta-cyclodextrins and their hydroxypropyl derivatives were converted by the reaction with chlorosulfonic acid in pyridine to the corresponding sulfates. Cyclodextrin sulfates were shown by fast-atom bombardment mass spectrometry (negative ion mode, tri-ethanolamine matrix) to be mixtures with nearly symmetrical distributions of degree of substitution by sulfate groups and by powder X-ray diffraction to be amorphous. Thus, in these aspects, cyclodextrin sulfates are similar to the potent drug solubilizers hydroxypropylcyclodextrins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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