New analogues of oxotremorine and oxotremorine-M
| Autor: | Marco De Amici, Carlo De Micheli, Clelia Dallanoce, Vigilio Ballabeni, Simona Bertoni, Mariannina Impicciatore, Elisabetta Barocelli |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Chemistry Vas deferens Muscarinic acetylcholine receptor M2 General Medicine Muscarinic acetylcholine receptor M1 General Biochemistry Genetics and Molecular Biology In vitro Guinea pig medicine.anatomical_structure Endocrinology Internal medicine Muscarinic acetylcholine receptor medicine Oxotremorine Potency General Pharmacology Toxicology and Pharmaceutics medicine.drug |
| Zdroj: | Life Sciences. 67:717-723 |
| ISSN: | 0024-3205 |
| Popis: | Two subsets of tertiary amines (1a-6a) and methiodides (1b-6b) with a structural resemblance to oxotremorine and oxotremorine-M were tested at rabbit vas deferens (M1), guinea pig left atrium (M2), guinea pig ileum and urinary bladder (M3) muscarinic receptor subtypes. The pharmacological profile of the derivatives under study has been discussed by evaluating their potency, affinity and efficacy as well as the regional differences in muscarinic receptor occupancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect