A Comparative Study of Efficacy and Tolerability of Fixed-Dose Combination of Etoricoxib and Thiocolchicoside versus Thiocolchicoside alone in Patients with Painful Muscle Spasms
| Autor: | Priyanka S Priyanka S, Manju J Manju J, Girish K Girish K |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biomedical and Pharmacology Journal. 15:353-361 |
| ISSN: | 2456-2610 0974-6242 |
| Popis: | Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants are widely prescribed for the highly prevalent painful muscle spasms. But there appears to be lack of published clinical study comparing the efficacy and tolerability with the intended study drugs. Aim: To compare the efficacy and tolerability of the fixed-dose combination (FDC) of Etoricoxib-Thiocolchicoside versus Thiocolchicoside alone in patients with painful muscle spasms. Materials and Methods: A prospective, open-label, randomized comparative study of 100 eligible outpatients with painful muscle spasms of either gender aged between 18 to 65 years were randomly assigned to receive oral medications b.i.d for 7 days of either FDC of Etoricoxib(60mg)-Thiocolchicoside(4mg)(GROUP-1) or Thiocolchicoside(4mg)(GROUP-2) alone. Results: The primary efficacy endpoint assessed by the percentage reduction in the intensity of pain utilizing a 10 cm Visual Analogue Scale (VAS) on movement and at rest was significant in both groups (p |
| Databáze: | OpenAIRE |
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